Prosthetic joint infection (PJI) represents one of the most common reasons for failure among hip and knee arthroplasty, with an incidence of around 1-2%. Infection can occur early (within days of surgery) or late (over a year after surgery), and no specific early markers for infection onset exist. Given the significant costs to the NHS for corrective revision surgery, the added suffering and risks to patients from surgery, and the risk of enhancing antimicrobial resistance through the use of broad-spectrum antibiotics, a more specific predictive test for early onset of infection is required.
Development of in-house bioinformatics tools and analysis models for use in combination with publicly available data analysis software
A list of commercial and academic sequencing facilities used by members of the faculty
Genotyping of ancient DNA from crew members from the Mary Rose to identfy phenotypic traits and disease traits
Metatranscriptomic analysis of marine biofilm composition on commercially available and novel anti-fouling substrates
Identification of differentially regulated gene pathways as a result of radiation exposure
Differential gene expression analysis in a model of Duchenne Muscular Dystrophy
Analysis of development in _Xenopus laevis_ using whole genome analysis