Kouzarides T

Latest

• Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells
• METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation
• SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
• Phosphorylation of histone H4T80 triggers DNA damage checkpoint recovery
• Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway
• Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
• A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation
• RNA binding by the histone methyltransferases Set1 and Set2
• A Chemical Probe for the ATAD2 Bromodomain
• Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy
• The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31
• Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia
• Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification
• BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms
• The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells
• Human RNA methyltransferase BCDIN3D regulates microRNA processing
• Three distinct patterns of histone H3Y41 phosphorylation mark active genes
• Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
• Nucleosome-interacting proteins regulated by DNA and histone methylation